Article
Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes
Author/s | Francos, Javier
Grande Carmona, Francisca Faustino, Hélio Iglesias Sigüenza, Francisco Javier Díez Martín, Elena Alonso, Isaac Fernández Fernández, Rosario Fátima Lassaletta, José M. López, Fernando Mascareñas, José L. |
Department | Universidad de Sevilla. Departamento de Química orgánica |
Publication Date | 2012 |
Deposit Date | 2022-11-11 |
Published in |
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Abstract | The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and ... The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and up to three stereocenters. Key to the success of the process is the use of newly designed axially chiral N-heterocyclic carbene-gold catalysts. |
Funding agencies | Ministerio de Economía y Competitividad (MINECO). España Xunta de Galicia Junta de Andalucía Fundação para a Ciência e a Tecnologia. Portugal |
Project ID. | SAF2010-20822-C02
CTQ2010-15297 CTQ2010-14974 CSD2007-00006 INCITE09209084PR GRC2010/12 2008/FQM-3833 2009/FQM-4537 SFRH/BD/60214/2009 |
Citation | Francos, J., Grande Carmona, F., Faustino, H., Iglesias Sigüenza, F.J., Díez Martín, E., Alonso, I.,...,Mascareñas, J.L. (2012). Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes. Journal of the American Chemical Society, 134 (35), 14322-14325. https://doi.org/10.1021/ja3065446. |
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