dc.creator | Sánchez-Hidalgo, Ana C. | es |
dc.creator | Martín-Cuevas, Celia | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.creator | Garrido-Torres, Nathalia | es |
dc.date.accessioned | 2022-11-09T14:48:28Z | |
dc.date.available | 2022-11-09T14:48:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sánchez-Hidalgo, A.C., Martín-Cuevas, C., Crespo Facorro, B. y Garrido-Torres, N. (2022). Reelin Alterations, Behavioral Phenotypes, and Brain Anomalies in Schizophrenia: A Systematic Review of Insights From Rodent Models. Frontiers in Neuroanatomy, 16, 844737. https://doi.org/10.3389/fnana.2022.844737. | |
dc.identifier.issn | 1662-5129 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139184 | |
dc.description.abstract | Reelin is an extracellular matrix glycoprotein reduced in brain regions (the prefrontal
cortex and the hippocampus) of patients with schizophrenia. There are diverse rodent
models of schizophrenia that mimic patient symptoms based on various causal theories;
however, likely shared reelin alterations have not yet been systematically assessed
in those models. A systematic review of the literature was conducted following the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model.
Articles focused on psychotic disorders or schizophrenia and their relationship with
reelin in rodent models were selected. Data (first author, publication year, results,
both open field and prepulse inhibition test results, and type of reelin alteration) were
extracted in duplicate by two independent reviewers. The 37 reviewed articles reported
about various schizophrenia models and their reelin alterations, brain morphology,
and behavioral defects. We conclude that reelin is an altered preclinical biomarker
common to all models included, mainly prenatal or genetic models, and a key protein in
schizophrenia disease, making the reelin signaling pathway in prenatal stages a target
of special interest for future preclinical and clinical studies. All models presented at least
one of the four described reelin alteration types. | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Neuroanatomy, 16, 844737. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Animal models | es |
dc.subject | Reelin | es |
dc.subject | Brain | es |
dc.subject | Neurodevelopment | es |
dc.subject | Extracellular matrix | es |
dc.title | Reelin Alterations, Behavioral Phenotypes, and Brain Anomalies in Schizophrenia: A Systematic Review of Insights From Rodent Models | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnana.2022.844737/full | es |
dc.identifier.doi | 10.3389/fnana.2022.844737 | es |
dc.contributor.group | Universidad de Sevilla. CTS1086 : Psiquiatría Traslacional. | es |
dc.journaltitle | Frontiers in Neuroanatomy | es |
dc.publication.volumen | 16 | es |
dc.publication.initialPage | 844737 | es |