Artículo
Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma
Autor/es | Sanegre, Sabina
Eritja, Núria Andrea, Carlos de Díaz-Martín, Juan Díaz-Lagares, Ángel Jácome, María Amalia Salguero-Aranda, Carmen Álava Casado, Enrique de Noguera, Rosa |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-11-09 |
Publicado en |
|
Resumen | The invasive tumor front (the tumor–host interface) is vitally important in malignant
cell progression and metastasis. Tumor cell interactions with resident and infiltrating
host cells and with the surrounding extracellular ... The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin- fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors. |
Agencias financiadoras | "Juan Rodes" from the ISCIII, JR17/00016 CIBERONC, CB16/12/00484; CB16/12/0328; CB16/12/00363; CB16/12/00364; CB16/12/00481; CB16/12/00231 ERDF, PI17/01558; PI20/01107 Grupos Coordinados Estables from the Asociacion Espanola Contra el Cancer (AECC) ISCIII, PI17/01558; PI20/01107 CB16/12/00364 |
Identificador del proyecto | JR17/00016
CB16/12/00484 CB16/12/0328 CB16/12/00363 CB16/12/00481 CB16/12/00231 ERDF, PI17/01558 PI20/01107 CB16/12/00364 |
Cita | Sanegre, S., Eritja, N., Andrea, C.d., Díaz-Martín, J., Díaz-Lagares, Á., Jácome, M.A. y Salguero-Aranda, C. (2021). Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.670185. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Characterizing the invasive tumor ... | 6.678Mb | [PDF] | Ver/ | |