dc.creator | García García, Amalia | es |
dc.creator | Rojas, Sara | es |
dc.creator | Rivas García, Lorenzo | es |
dc.creator | Navarro Hortal, María D. | es |
dc.creator | Romero Márquez, José M. | es |
dc.creator | Fernández-Bolaños Guzmán, José María | es |
dc.creator | López López, Óscar | es |
dc.creator | Rodríguez-Diéguez, Antonio | es |
dc.date.accessioned | 2022-11-04T12:25:55Z | |
dc.date.available | 2022-11-04T12:25:55Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | García García, A., Rojas, S., Rivas García, L., Navarro Hortal, M.D., Romero Márquez, J.M., Fernández-Bolaños Guzmán, J.M.,...,Rodríguez-Diéguez, A. (2022). A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans. Chemical Communications, 58, 1514-1517. https://doi.org/10.1039/d1cc04404d. | |
dc.identifier.issn | 1359-7345 | es |
dc.identifier.issn | 1364-548X | es |
dc.identifier.uri | https://hdl.handle.net/11441/138977 | |
dc.description.abstract | A new palladium coordination compound based on gliclazide with
the chemical formula [Pd(glz)2] (where glz = gliclazide) has been
synthesized and characterised. The structural characterization
reveals that this material consists of mononuclear units formed by
a Pd2+ ion coordinated to two molecules of the glz ligand, in which
palladium ions exhibit a distorted plane-square coordination
sphere. This novel material behaves like a good and selective
inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer’s disease. Analysis of the enzyme
kinetics showed a mixed mode of inhibition, the title compound
being capable of interacting with both the free enzyme and the
enzyme–substrate complex. Finally, the palladium compound
shows promising protective activity against Ab-induced toxicity in
the Caenorhabditis elegans model, which has never been reported. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Chemical Communications, 58, 1514-1517. | |
dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.publisherversion | http://doi.org/10.1039/d1cc04404d | es |
dc.identifier.doi | 10.1039/d1cc04404d | es |
dc.journaltitle | Chemical Communications | es |
dc.publication.volumen | 58 | es |
dc.publication.initialPage | 1514 | es |
dc.publication.endPage | 1517 | es |