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Pd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazones

dc.creatorKattela, Shivashankares
dc.creatorRoque D. Correia, Carloses
dc.creatorRos, Abeles
dc.creatorHornillos Gómez-Recuero, Valentínes
dc.creatorIglesias Sigüenza, Francisco Javieres
dc.creatorFernández Fernández, Rosarioes
dc.creatorLassaletta Simón, José Maríaes
dc.date.accessioned2022-10-04T10:56:38Z
dc.date.available2022-10-04T10:56:38Z
dc.date.issued2022
dc.identifier.citationKattela, S., Roque D. Correia, C., Ros, A., Hornillos Gómez-Recuero, V., Iglesias Sigüenza, F.J., Fernández Fernández, R. y Lassaletta Simón, J.M. (2022). Pd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazones. Organic Letters, 24 (21), 3812-3816. https://doi.org/10.1021/acs.orglett.2c01355.
dc.identifier.issn1523-7052es
dc.identifier.urihttps://hdl.handle.net/11441/137599
dc.description.abstractA dynamic kinetic asymmetric Pd-catalyzed cross-coupling reaction of heterobiaryl bromides with ketone N-tosylhydrazones for the synthesis of heterobiaryl styrenes is described. The combination of Pd(dba)2 as a precatalyst with a TADDOL-derived phosphoramidite ligand provides the corresponding coupling products in good yields and high enantioselectivities under mild conditions. Racemization-free N-oxidation and N-alkylation of the products allowed us to obtain appealing functionalized axially chiral heterobiaryl derivatives.es
dc.description.sponsorshipSpanish Ministerio de Ciencia e Innovación (Grants PID2019-106358GB-C21 and PID2019- 106358GB-C22 and Contract RYC-2013-12585 for A.R. and Contract RYC-2017-22294 for V.H.)es
dc.description.sponsorshipEspaña Junta de Andalucía (Grants P18-FR-3531, P18-FR-644, US-1262867, and US-1260906)es
dc.formatapplication/pdfes
dc.format.extent5 p.es
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.relation.ispartofOrganic Letters, 24 (21), 3812-3816.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazoneses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDPID2019- 106358GB-C22es
dc.relation.projectIDPID2019-106358GB-C21es
dc.relation.projectIDP18-FR-3531, P18-FR-644, US-1262867, US-1260906es
dc.relation.publisherversionhttps://dx.doi.org/10.1021/acs.orglett.2c01355es
dc.identifier.doi10.1021/acs.orglett.2c01355es
dc.journaltitleOrganic Letterses
dc.publication.volumen24es
dc.publication.issue21es
dc.publication.initialPage3812es
dc.publication.endPage3816es
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes

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