Article
Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients
Author/s | Riccio, Maria E.
Verschuuren, Tess Conzelmann, Nadine Martak, Daniel Meunier, Alexandre Salamanca, Elena Rodríguez-Baño, Jesús Pascual Hernández, Álvaro Musicha, Patrick |
Department | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Microbiología |
Publication Date | 2021 |
Deposit Date | 2022-09-20 |
Published in |
|
Abstract | Objectives: This study aimed to determine rates and risk factors of extended-spectrum b-lactamaseproducing
Enterobacteriaceae (ESBL-PE) acquisition and transmission within households after hospital
discharge of an ... Objectives: This study aimed to determine rates and risk factors of extended-spectrum b-lactamaseproducing Enterobacteriaceae (ESBL-PE) acquisition and transmission within households after hospital discharge of an ESBL-PE-positive index patient. Methods: Two-year prospective cohort study in five European cities. Patients colonized with ESBLproducing Escherichia coli (ESBL-Ec) or Klebsiella pneumoniae (ESBL-Kp), and their household contacts were followed up for 4 months after hospital discharge of the index case. At each follow up, participants provided a faecal sample and personal information. ESBL-PE whole-genome sequences were compared using pairwise single nucleotide polymorphism-based analysis. Results: We enrolled 71 index patients carrying ESBL-Ec (n ¼ 45), ESBL-Kp (n ¼ 20) or both (n ¼ 6), and 102 household contacts. The incidence of any ESBL-PE acquisition among household members initially free of ESBL-PE was 1.9/100 participant-weeks at risk. Nineteen clonally related household transmissions occurred (case to contact: 13; contact to case: 6), with an overall rate of 1.18 transmissions/100 participant-weeks at risk. Most of the acquisition and transmission events occurred within the first 2 months after discharge. The rate of ESBL-Kp household transmission (1.16/100 participant-weeks) was higher than of ESBL-Ec (0.93/100 participant-weeks), whereas more acquisitions were noted for ESBL-Ec (1.06/100 participant-weeks) compared with ESBL-Kp (0.65/100 participant-weeks). Providing assistance for urinary and faecal excretion to the index case by household members increased the risk of ESBL-PE transmission (adjusted prevalence ratio 4.3; 95% CI 1.3e14.1). |
Project ID. | REIPI RD16/0016/ 0001 |
Citation | Riccio, M.E., Verschuuren, T., Conzelmann, N., Martak, D., Meunier, A., Salamanca, E.,...,Musicha, P. (2021). Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients. Clinical Microbiology and Infection, 27 (9), 1322-1329. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Household...pdf | 899.2Kb | [PDF] | View/ | |