Artículo
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Autor/es | Navarro Pando, José Manuel
Alcocer-Gómez, Elísabet Castejón Vega, Beatriz Navarro Villarán, Elena Condés Hervás, Mónica Mundi Roldán, María Muntané Relat, Jordi Pérez Pulido, Antonio J. Bullon, Pedro Wang, Chun Hoffman, Hal M. Sanz Montero, Alberto Mbalaviele, Gabriel Ryffel, Bernhard Cordero, Mario D. |
Departamento | Universidad de Sevilla. Departamento de Psicología Experimental |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-08-25 |
Publicado en |
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Resumen | Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of ... Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility |
Cita | Navarro Pando, J.M., Alcocer Gómez, E.I., Castejón Vega, B., Navarro Villarán, E., Condés Hervás, M., Mundi Roldán, M.,...,Cordero, M.D. (2021). Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances, 7 (1), Article 7409. |
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