Artículo
Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors
Autor/es | Guardiola, Consuelo
Bachiller Perea, Diana Prieto Pena, Juan Jiménez Ramos, María del Carmen García López, Francisco Javier Esnault, Cedric Fleta Corral, María Celeste Quirión, David Gómez Rodríguez, Faustino |
Departamento | Universidad de Sevilla. Departamento de Física Aplicada II Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear |
Fecha de publicación | 2021-05 |
Fecha de depósito | 2022-07-22 |
Publicado en |
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Resumen | In this work we show the first microdosimetry measurements on a low energy proton beam with therapeutic-equivalent fluence rates by using the second generation of 3D-cylindrical microdetectors. The sensors belong to an ... In this work we show the first microdosimetry measurements on a low energy proton beam with therapeutic-equivalent fluence rates by using the second generation of 3D-cylindrical microdetectors. The sensors belong to an improved version of a novel silicon-based 3D-microdetector design with electrodes etched inside silicon, which were manufactured at the National Microelectronics Centre (IMB-CNM, CSIC) in Spain. A new microtechnology has been employed using quasi-toroid electrodes of 25μm diameter and a depth of 20μm within the silicon bulk, resulting in a well-defined cylindrical radiation sensitive volume. These detectors were tested at the 18 MeV proton beamline of the cyclotron at the National Accelerator Centre (CNA, Spain). They were assembled into an in-house low-noise readout electronics to assess their performance at a therapeutic-equivalent fluence rate. Microdosimetry spectra of lineal energy were recorded at several proton energies starting from 18 MeV by adding 50μm thick tungsten foils gradually at the exit-window of the cyclotron external beamline, which corresponds to different depths along the Bragg curve. The experimentalyF¯values in silicon cover from (5.7 ± 0.9) to (8.5 ± 0.4) keV μm-1in the entrance to (27.4 ± 2.3) keV μm-1in the distal edge. Pulse height energy spectra were crosschecked with Monte Carlo simulations and an excellent agreement was obtained. This work demonstrates the capability of the second generation 3D-microdetectors to assess accurate microdosimetric distributions at fluence rates as high as those used in clinical centers in proton therapy. |
Agencias financiadoras | MICIN |
Identificador del proyecto | RTI2018-098117-B-C2 |
Cita | Guardiola, C., Bachiller Perea, D., Prieto Pena, J., Jiménez Ramos, M.d.C., García López, F.J., Esnault, C.,...,Gómez Rodríguez, F. (2021). Microdosimetry in low energy proton beam at therapeutic-equivalent fluence rate with silicon 3D-cylindrical microdetectors. Physics in Medicine & Biology, 66 (11(114001)) |
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