Artículo
Autism and Williams syndrome: Dissimilar socio-cognitive profiles with similar patterns of abnormal gene expression in the blood
Autor/es | Benítez Burraco, Antonio
Niego, Amy |
Departamento | Universidad de Sevilla. Departamento de Lengua Española, Lingüística y Teoría de la Literatura |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-07-15 |
Publicado en |
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Resumen | Autism spectrum disorders and Williams syndrome exhibit quite opposite features in the social domain, but also
share some common underlying behavioral and cognitive deficits. It is not clear, however, which genes account ... Autism spectrum disorders and Williams syndrome exhibit quite opposite features in the social domain, but also share some common underlying behavioral and cognitive deficits. It is not clear, however, which genes account for the attested differences (and similarities) in the socio-cognitive domain. In this article, we adopted a comparative molecular approach and looked for genes that might be differentially (or similarly) regulated in the blood of subjects with these two conditions. We found a significant overlap between differentially expressed genes compared to neurotypical controls, with most of them exhibiting a similar trend in both conditions, but with genes being more dysregulated in Williams syndrome than in autism spectrum disorders. These genes are involved in aspects of brain development and function (particularly dendritogenesis) and are expressed in brain areas (particularly the cerebellum, the thalamus, and the striatum) of relevance for the autism spectrum disorder and the Williams syndrome etiopathogenesis |
Cita | Benítez Burraco, A. y Niego, A. (2021). Autism and Williams syndrome: Dissimilar socio-cognitive profiles with similar patterns of abnormal gene expression in the blood. Autism, 25 (2), 464-489. |
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