Artículo
Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform
Autor/es | García León, Juan Antonio
Vitorica Ferrández, Francisco Javier Gutiérrez Pérez, Antonia |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Fecha de publicación | 2019 |
Fecha de depósito | 2022-07-04 |
Publicado en |
|
Resumen | Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies ... Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions. |
Cita | García León, J.A., Vitorica Ferrández, F.J. y Gutiérrez Pérez, A. (2019). Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. Future Medicinal Chemistry, 11 (11), 1305-1322. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
fmc-2018-0520.pdf | 1.082Mb | [PDF] | Ver/ | |