Article
Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies
Author/s | Carmona, José A.
Rodríguez Franco, Carlos Fernández Fernández, Rosario Fátima Hornillos, Valentín Lassaletta, José M. |
Department | Universidad de Sevilla. Departamento de Química orgánica |
Publication Date | 2021 |
Deposit Date | 2022-04-20 |
Published in |
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Abstract | This tutorial review provides a systematic overview of the available methodologies for the
atroposelective transformation of (heterobiaryl)biaryl precursors toward the synthesis of enantiomerically
enriched products and ... This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation of (heterobiaryl)biaryl precursors toward the synthesis of enantiomerically enriched products and the conceptual aspects associated to each type of transformation. Depending on the presence or absence of symmetry in the starting material and the participation of racemization or dynamization events along the process, several strategies have been developed, including desymmetrization, classical kinetic resolution (KR), dynamic kinetic resolution (DKR) and dynamic kinetic asymmetric transformation (DYKAT). Seminal contributions and a handful of selected examples are discussed to illustrate the potential of these synthetic tools. |
Funding agencies | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía |
Project ID. | P18-FR-3531
P18-FR-644 US-1262867 US-1260906 |
Citation | Carmona, J.A., Rodríguez Franco, C., Fernández Fernández, R.F., Hornillos, V. y Lassaletta, J.M. (2021). Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies. Chemical Society Reviews, 50 (5), 2968-2983. |
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