Article
One step back before moving forward: regulation of transcription elongation by arrest and backtracking
Author/s | Gómez Herreros, Fernando
Miguel Jiménez, María Dolores De Millán Zambrano, Gonzalo Peñate Salas, Xenia Delgado Ramos, Lidia Muñoz Centeno, María de la Cruz Chávez de Diego, Sebastián |
Department | Universidad de Sevilla. Departamento de Genética |
Publication Date | 2012 |
Deposit Date | 2022-03-22 |
Published in |
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Abstract | RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches ... RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches are shedding some light on this interesting aspect of gene transcription. In this review, we briefly summarise these new findings, comment about some results recently obtained in our laboratory, and propose a new model for the influence of the chromatin context on RNA polymerase II backtracking. |
Funding agencies | Ministerio de Economía y Competitividad (MINECO). España Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Project ID. | BFU2007-67575-C03-02
BFU-2010-21975-C03-03 P07-CVI-02623 P08-CVI-03508 |
Citation | Gómez Herreros, F., Miguel Jiménez, M.D.D., Millán Zambrano, G., Peñate Salas, X., Delgado Ramos, L., Muñoz Centeno, M.d.l.C. y Chávez de Diego, S. (2012). One step back before moving forward: regulation of transcription elongation by arrest and backtracking. FEBS Letters, 586 (18), 2820-2825. |
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