Artículo
Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy
Autor/es | Christou, Evangelia
Pearson, John R. Beltrán, Ana M. Fernández-Afonso, Yilian Gutiérrez, Lucía Fuente, Jesús M. de la Gámez, Francisco García-Martín, María L. Caro, Carlos |
Departamento | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Fecha de publicación | 2022-03 |
Fecha de depósito | 2022-03-16 |
Publicado en |
|
Resumen | The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. ... The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM−1⋅s−1) and X-ray attenuation properties (8.8 HU mM−1⋅HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (∆T ≈ 2.5 °C) and Near-Infrared (NIR) light (∆T ≈ 17 °C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications. |
Identificador del proyecto | CTQ2017-86655-R
PID2020-118448RB-C21 PID2020-113108RB-I00 MCIN/AEI/10.13039/501100011033 PGC2018-096016-B-I00 OH-0026-2018 PAIDI 2020. P20_00727 |
Cita | Christou, E., Pearson, J.R., Beltrán, A.M., Fernández-Afonso, Y., Gutiérrez, L., Fuente, J.M.d.l.,...,Caro, C. (2022). Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy. Pharmaceutics, 14 (3), 636-. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
P_beltran-custodio_2022_iron.pdf | 2.268Mb | [PDF] | Ver/ | |