Artículo
Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome
Autor/es | Montserrat de la Paz, Sergio
Naranjo, Maria C. López Martín, Sergio Abia González, María del Rocío García Muriana, Francisco José Bermúdez Pulgarín, Beatriz |
Departamento | Universidad de Sevilla. Departamento de Biología Celular Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2016 |
Fecha de depósito | 2022-03-14 |
Publicado en |
|
Resumen | We aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination ... We aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination with niacin (NA) on atherosclerotic plaque characteristics in a mouse model (Lepob/obLDLR−/−) of metabolic syndrome (MetS). Compared to a low-fat low-cholesterol diet (LFLCD), HFLCDs increased body weight, triglycerides, insulin, pro-inflammatory cytokines, and circulating monocytes, contributing the HFLCD-SFAs to a predominance of a classical pro-inflammatory Ly6Chi population, whereas HFLCD-MUFAs and HFLCD-PUFAs to a non-classical patrolling Ly6Clo population. HFLCDs promoted atherosclerosis in the aortic roots of animals but the plaque size, collagen, and macrophage content were higher with the HFLCD-SFAs than with the HFLCD-MUFAs or HFLCD-PUFAs. Furthermore, HFLCD-SFAs promoted the intra-plaque accumulation of M1 macrophages, whereas HFLCD-MUFAs and HFLCD-PUFAs favoured the accumulation of M2 macrophages. These data suggest that dietary MUFAs had advantage over SFAs to prevent atherosclerotic events in the NA-treated MetS. |
Identificador del proyecto | AGL2011-29008 |
Cita | Montserrat de la Paz, S., Naranjo, M.C., López Martín, S., Abia González, M.d.R., García Muriana, F.J. y Bermúdez Pulgarín, B. (2016). Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome. Journal of Functional Foods, 26, 557-564. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Olive oil compared to a saturated ... | 737.8Kb | [PDF] | Ver/ | |