dc.creator | Gómez Oliva, Ricardo | es |
dc.creator | Geribaldi Doldán, Noelia | es |
dc.creator | Domínguez García, Samuel | es |
dc.creator | Carrascal Moreno, María Livia | es |
dc.creator | Verástegui, Cristina | es |
dc.creator | Núñez Abades, Pedro Antonio | es |
dc.creator | Castro, Carmen | es |
dc.date.accessioned | 2022-03-02T07:55:20Z | |
dc.date.available | 2022-03-02T07:55:20Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Gómez Oliva, R., Geribaldi Doldán, N., Domínguez García, S., Carrascal Moreno, M.L., Verástegui, C., Núñez Abades, P.A. y Castro, C. (2020). Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling. Aging, 12 (13), 13824-13844. | |
dc.identifier.issn | 1945-4589 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130298 | |
dc.description.abstract | Vitamin D is an essential fat-soluble vitamin that participates in several homeostatic functions in mammalian
organisms. Lower levels of vitamin D are produced in the older population, vitamin D deficiency being an
accelerating factor for the progression of the aging process. In this review, we focus on the effect that vitamin D
exerts in the aged brain paying special attention to the neurogenic process. Neurogenesis occurs in the adult
brain in neurogenic regions, such as the dentate gyrus of the hippocampus (DG). This region generates new
neurons that participate in cognitive tasks. The neurogenic rate in the DG is reduced in the aged brain because
of a reduction in the number of neural stem cells (NSC). Homeostatic mechanisms controlled by the Wnt
signaling pathway protect this pool of NSC from being depleted. We discuss in here the crosstalk between Wnt
signaling and vitamin D, and hypothesize that hypovitaminosis might cause failure in the control of the
neurogenic homeostatic mechanisms in the old brain leading to cognitive impairment. Understanding the
relationship between vitamin D, neurogenesis and cognitive performance in the aged brain may facilitate
prevention of cognitive decline and it can open a door into new therapeutic fields by perspectives in the
elderly. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades RTI2018-099908-B-C21 | es |
dc.description.sponsorship | FEDER-UCA18-10664 | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | Impact Journals LLC | es |
dc.relation.ispartof | Aging, 12 (13), 13824-13844. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | RTI2018-099908-B-C21 | es |
dc.relation.projectID | FEDER-UCA18-10664 | es |
dc.relation.publisherversion | http://dx.doi.org/10.18632/aging.103510 | es |
dc.identifier.doi | 10.18632/aging.103510 | es |
dc.journaltitle | Aging | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 13824 | es |
dc.publication.endPage | 13844 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |