Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
Autor/es | Ortega Moreno, Pedro
Gómez González, Belén Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2021 |
Fecha de depósito | 2021-09-01 |
Publicado en |
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Resumen | It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ... It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication. |
Cita | Ortega Moreno, P., Gómez González, B.M. y Aguilera López, A. (2021). Heterogeneity of DNA damage incidence and repair in different chromatin contexts. DNA Repair, 107, 103210. |
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