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Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage ...
Artículo
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible ...
Artículo
Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA ...
Artículo
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid ...
Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome integrity. The readout of DSB repair may depend on whether DSBs occur at transcribed versus ...