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Mostrando ítems 71-80 de 166
Artículo
CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
(Cold Spring Harbor Laboratory Press, 2021)
In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular metabolism, cell cycle progression, and DNA repair. Among many other events, recent evidence has ...
Artículo
Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells
(Springer Nature, 2019-09)
Aims/hypothesis: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical that has been associated with type 2 diabetes development. Low doses of BPA modify pancreatic beta cell function and induce insulin resistance; ...
Artículo
Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. The use of new techniques based on tandem affinity purification (TAP) and chromatin immunoprecipitation ...
Artículo
PTTG2 silencing results in induction of epithelial-to-mesenchymal transition and apoptosis
(Nature Publishing Group, 2013)
Human securin, also known as human pituitary tumor-transforming gene 1 (pttg1), plays a key role in cell-cycle regulation. Two homologous genes, pttg2 and pttg3, have been identified although very little is known about ...
Artículo
Disease-Causing Mutations in BEST1 Gene Are Associated with Altered Sorting of Bestrophin-1 Protein
(MDPI, 2013)
Mutations in BEST1 gene, encoding the bestrophin-1 (Best1) protein are associated with macular dystrophies. Best1 is predominantly expressed in the retinal pigment epithelium (RPE), and is inserted in its basolateral ...
Artículo
ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
(MDPI, 2022)
High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack of effective treatments. Therefore, the development of new therapeutic strategies to treat these ...
Artículo
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop ...
Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts ...
Artículo
Distinct responses of human peripheral blood cells to different misfolded protein oligomers
(Wiley-Blackwell, 2021)
Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein misfolding, which are associated with formation of aberrant aggregates, including soluble protein ...