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Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival. Herein, we investigated the cell death mechanism activated in ...
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Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)
Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic targets for ovarian cancer. ShRNA screen performed in 42 ovarian cancer cell lines identified the ...
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267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation
(Oxford University Press, 2016)
Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical purposes, differ considerably across different populations. The need for a detailed catalog of local ...
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)
DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
(MDPI, 2021)
Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible mushroom Agaricus bisporus (AB) ...
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Cryopreservation of GABAergic neuronal precursors for cell-based therapy
(Public Library of Science, 2017)
Cryopreservation protocols are essential for stem cells storage in order to apply them in the clinic. Here we describe a new standardized cryopreservation protocol for GABAergic neural precursors derived from the medial ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
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CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
(Cold Spring Harbor Laboratory Press, 2021)
In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular metabolism, cell cycle progression, and DNA repair. Among many other events, recent evidence has ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop ...
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Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
(Nature Publishing Group:, 2018)
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope ...