Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por fecha de publicación
Mostrando ítems 41-60 de 167
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Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
(Elsevier, 2015)DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia ...
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Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
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FANCD2 facilitates replication through common fragile sites
(Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation
(Oxford University Press, 2016)Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical ...
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Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
(Anatomical Society of Great Britain and Ireland, John Wiley & Sons, 2016)Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies ...
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Transcriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa
(Nature Publishing Group, 2016)PRPF31-associated retinitis pigmentosa presents a fascinating enigma: some mutation carriers are blind, while others are ...
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PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
(Springer Nature, 2016)[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, ...
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Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
(eLife Sciences Publications, 2016)Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms ...
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SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, ...
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Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs
(Elsevier, 2016)Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells ...
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TOPORS, a dual E3 ubiquitin and Sumo1 ligase, interacts with 26 S protease regulatory subunit 4, encoded by the PSMC1 gene
(Public Library of Science, 2016)The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of ...
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Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity
(Public Library of Science, 2016)Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The ...
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MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1
(Company of Biologists, 2016)Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the ...
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
(MDPI AG, 2016)Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder
(Elsevier, 2016)From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) ...
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
(Cold Spring Harbor Laboratory Press, 2016)Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes ...
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Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation
(Elsevier, 2017)The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic ...
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Analysis of the relationship between coexpression domains and chromatin 3D organization
(Public Library of Science, 2017)Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that ...
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The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)