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Now showing items 1-10 of 25
Article
In vitro activity of pentamidine alone and in combination with antibiotics against multidrug-resistant clinical Pseudomonas aeruginosa strains
(MDPI, 2020-12-09)
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a public health problem causing both community and hospital-acquired infections, and thus the development of new therapies for these infections is critical. The objective ...
Article
SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome
(NATURE PUBLISHING GROUP, 2021)
The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with ...
Article
Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii
(Taylor and Francis, 2020)
Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We ...
Article
Repurposing of the tamoxifen metabolites to combat infections by multidrug-resistant gram-negative bacilli
(Multidisciplinary Digital Publishing Institute, 2021-03-22)
The development of new strategic antimicrobial therapeutic approaches, such as drug repurposing, has become an urgent need. Previously, we reported that tamoxifen presents therapeutic efficacy against multidrug-resistant ...
Article
Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone
(Frontiers Media S.A., 2024-01-24)
Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available. In this study, we ...
Article
Evaluation of nutritional interventions in the care plan for cancer patients: the NOA project
(MDPI, 2023)
The NOA (Oncological Nutrition in Andalusia) project analyses the degree of integration and areas of improvement in implementing nutritional support in the care plans of cancer patients in Andalusia. The aim was to analyse ...
Article
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: a prospective multicenter cohort study
(Public Library Science, 2021)
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observa tional cohort study of 210 consecutive SOTRs ...
Article
Potential tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli
(2021-05-26)
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as monotherapies or in combination with clinically relevant ...
Article
Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score
(BMJ PUBLISHING GROUP, 2021)
Objective: To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms. Design Multivariable prognostic prediction model. Setting 127 Spanish hospitals. P ...
Article
Carbapenem Combinations for Infections Caused by Carbapenemase-Producing Pseudomonas aeruginosa: Experimental In Vitro and In Vivo Analysis
(MDPI, 2022-09-07)
In the context of difficult-to-treat carbapenem-resistant Pseudomonas aeruginosa infections, we evaluated imipenem, meropenem, and doripenem combinations against eleven carbapenemase-producing P. aeruginosa isolates. ...