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Mostrando ítems 31-40 de 40
Artículo
T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients
(FERRATA STORTI FOUNDATION, 2021-01)
Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. In adult recipients, prospective studies addressing the incidence ...
Artículo
A phase II, prospective, randomized, open-label study of defibrotide added to standard-of-care prophylaxis for the prevention of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
(Ferrata Storti Foundation, 2023)
Acute graft-versus-host disease (aGvHD) is a life-threatening complication typically occurring within 100 days after allogeneic hematopoietic cell transplantation (allo-HCT). This hypothesis-generating, phase II, prospective, ...
Artículo
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
(Springer Nature, 2023)
Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to European LeukemiaNet (ELN) guidelines. We validated and compared the 2022 ELN risk classification ...
Artículo
Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring
(Frontiers Media S.A., 2024-01-16)
Introduction: Loss of B-cell aplasia (BCA) is a well-known marker of functional loss of CD19 CAR-T. Most relapses and loss of BCA occur in the first months after CD19 CAR-T infusion. In addition, high tumor burden (HTB) ...
Artículo
Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry
(Ferrata Storti Foundation, 2024)
Treatment options for patients with secondary acute myeloid leukemia (sAML) and AML with myeloid-related changes (AMLMRC) aged 60 to 75 years are scarce and unsuitable. A pivotal trial showed that CPX-351 improved complete ...
Artículo
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression
(Frontiers Media S.A., 2023)
Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological ...
Artículo
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
(Frontiers Media S.A., 2023-12-11)
Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD (SR-aGVHD). Based on recent Phase-III study results, ruxolitinib has become the new standard of ...
Artículo
Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia
(Elsevier, 2023-01-10)
Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect survival. However, it remains uninvestigated during routine diagnostic workups. We hypothesized ...
Artículo
Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021-10-21)
Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In heavily pretreated patients, who have already received proteasome inhibitors, immunomodulatory drugs ...
Artículo
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, ...