Buscar
Mostrando ítems 261-269 de 269
Artículo
SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome
(NATURE PUBLISHING GROUP, 2021)
The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with ...
Artículo
Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: a prospective multicenter cohort study
(Public Library Science, 2021)
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observa tional cohort study of 210 consecutive SOTRs ...
Artículo
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial
(BMJ Publishing Group, 2021)
Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant Enterobacterales (3GCR-E). Temocillin is a suitable candidate, but comparative randomised studies are lacking. ...
Artículo
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
(Elsevier Science BV, 2021)
Background & Aims Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ...
Artículo
CD46 Genetic Variability and HIV-1 Infection Susceptibility
(MDPI, 2021-11-09)
CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, ...
Artículo
Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021-10-21)
Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In heavily pretreated patients, who have already received proteasome inhibitors, immunomodulatory drugs ...
Artículo
Liver manifestations in COVID-19 and the influence of pre-existing liver disease in the course of the infection
(Arán Ediciones, S.L., 2021)
Introduction: patients with advanced chronic liver disease (CLD) may be at an increased risk of a severe course due to cirrhosis-associated immune dysfunction. The aim of this study was to determine the prevalence of ...
Artículo
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
(Aran Ediciones S.A., 2021)
Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact of baseline liver function (aspartate aminotransfer ase [AST], alanine aminotransferase [ALT], ...
Artículo
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, ...