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Mostrando ítems 671-680 de 701
Artículo
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial
(BMJ Publishing Group, 2021)
Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant Enterobacterales (3GCR-E). Temocillin is a suitable candidate, but comparative randomised studies are lacking. ...
Artículo
Low CD4/CD8 ratio is associated with increased morbidity and mortality in late and non‑late presenters: results from a multicentre cohort study, 2004–2018
(Biomed Central LTD, 2022)
Background: To study whether the association between the CD4/CD8 ratio variation over time and the develop‑ ment of clinical outcomes vary in late presenters (CD4 count<350/µL or AIDS event at enrolment) or advanced ...
Artículo
Predicting 30-Day Readmission Risk for Patients With Chronic Obstructive Pulmonary Disease Through a Federated Machine Learning Architecture on Findable, Accessible, Interoperable, and Reusable (FAIR) Data: Development and Validation Study
(JMIR Publications, 2022)
Background: Owing to the nature of health data, their sharing and reuse for research are limited by legal, technical, and ethical implications. In this sense, to address that challenge and facilitate and promote the ...
Artículo
Hidradenitis suppurativa and suicide risk: a multivariate analysis in a disease with a high psychological burden
(Springer, 2023)
Background: Hidradenitis suppurativa (HS) is a disorder that can lead to serious sequelae and important comorbidities. It has been associated with different mental health conditions, such as depression, anxiety or completed ...
Artículo
A phase II, prospective, randomized, open-label study of defibrotide added to standard-of-care prophylaxis for the prevention of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
(Ferrata Storti Foundation, 2023)
Acute graft-versus-host disease (aGvHD) is a life-threatening complication typically occurring within 100 days after allogeneic hematopoietic cell transplantation (allo-HCT). This hypothesis-generating, phase II, prospective, ...
Artículo
Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
(Springer Nature, 2023)
Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to European LeukemiaNet (ELN) guidelines. We validated and compared the 2022 ELN risk classification ...
Artículo
Safe use of proton-pump inhibitors
(Aran Ediciones S.A., 2023)
Proton-pump inhibitors (PPIs) are one of the most widely used drug classes worldwide. Their discovery goes back to the 1980s, when the significance of H+/K+-ATPase in gastric acid production was established. The market ...
Artículo
The HLA-DQA1*05 genotype does not influence the clinical response to ustekinumab and vedolizumab
(Aran Ediciones S.A., 2023)
Background: the success of strategies with earlier anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) have been shadowed by the development of an ti-drug antibodies that reduce their effectiveness. ...
Artículo
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
(Elsevier Science BV, 2021)
Background & Aims Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ...
Artículo
Epidemiology and risk factors of mycotic aneurysm in patients with infective endocarditis and the impact of its rupture in outcomes. Analysis of a national prospective cohort
(Oxford Univ Press, 2024)
Background. Several aspects of the occurrence and management of mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied. Objectives. To determine the incidence and factors associated with ...