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Artículo
In vitro activity of pentamidine alone and in combination with antibiotics against multidrug-resistant clinical Pseudomonas aeruginosa strains
(MDPI, 2020-12-09)
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a public health problem causing both community and hospital-acquired infections, and thus the development of new therapies for these infections is critical. The objective ...
Tesis Doctoral
Aislamiento, purificación y caracterización de los alérgenos presentes en la semilla de lupinus albus (altramuz)
(2002-11-18)
El problema principal que nos encontramos al estudiar la alergia alimentaria al Lupinus albus, es que los alérgenos mayores no están identificados y son desconocidos, esto ocasiona que no hayan las herramientas correctas ...
Tesis Doctoral
Estudio clínico de las miopatías relacionadas con el ejercicio
(1999-03-22)
Las manifestaciones clínicas relacionadas con el ejercicio como mialgias, calambres, espasmos, contracturas musculares, IE, mioglobinuria, fatiga precoz, debilidad o paresias musculares (independientemente de su intensidad), ...
Artículo
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial
(BMC, 2024)
Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At ...
Artículo
Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
(Nature Publishing Group, 2021)
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are ...
Artículo
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients
(SPRINGER, 2022)
Parkinson’s disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis ...
Artículo
Adjuvant nivolumab versus ipilimumab (CheckMate 238 trial): Reassessment of 4-year efficacy outcomes in patients with stage III melanoma per AJCC-8 staging criteria
(Elsevier Science Ltd, 2022)
Abstract Purpose: Nivolumab was approved as adjuvant therapy for melanoma based on data from CheckMate 238, which enrolled patients per American Joint Committee on Cancer version 7 (AJCC-7) criteria. Here, we analyse ...
Artículo
Incidence, morbidity and mortality of hip fractures over a period of 20 years in a health area of Southern Spain
(BMJ Journals, 2020)
Objective To evaluate the incidence of osteoporotic hip fracture in the Macarena Health Area (Seville). Setting and participants This was a prospective observational study that collected all osteoporotic hip fractures ...
Tesis Doctoral
Artículo
Non-Melanoma Skin Cancer Mortality in Spain: A Predictive Model up to 2044
(MDPI, 2021-12-08)
Non-melanoma skin cancers (NMSC) are the most common malignancies worldwide and are, worryingly, increasing in incidence. However, data in the literature on NMSC specific mortality are scarce, because these tumors are ...