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Artículo
The role of non-coding RNAs in autophagy during carcinogenesis
(Frontiers Media S.A., 2022)
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway involved in self-renewal and quality control processes to maintain cellular homeostasis. The alteration of autophagy has been implicated ...
Artículo
SOS GEFs in health and disease
(Elsevier, 2020)
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are ...
Artículo
Role of the holoenzyme PP1-SPN in the dephosphorylation of the rb family of tumor suppressors during cell cycle
(MDPI, 2021-05-06)
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance ...