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Artículo
Transcriptomic and connectomic correlates of differential spatial patterning among gliomas
(Oxford University Press, 2022-10-18)
Unravelling the complex events driving grade-specific spatial distribution of brain tumour occurrence requires rich datasets from both healthy individuals and patients. Here, we combined open-access data from The Cancer ...
Artículo
Brain charts for the human lifespan
(Nature Publishing Group, 2022)
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual diferences in ...
Artículo
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
(Nature Portfolio, 2020)
Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into ...
Artículo
A deep graph neural network architecture for modelling spatio-temporal dynamics in resting-state functional MRI data
(Elsevier Science B.V, 2022)
Resting-state functional magnetic resonance imaging (rs-fMRI) has been successfully employed to understand the organisation of the human brain. Typically, the brain is parcellated into regions of interest (ROIs) and modelled ...
Artículo
Brain micro-architecture and disinhibition a latent phenotyping study across 33 impulsive and compulsive behaviours
(Nature Publishing Group, 2020-09-12)
Impulsive and compulsive symptoms are common, tend to co-occur, and collectively account for a substantive global disease burden. Latent phenotyping offers a promising approach to elucidate common neural mechanisms conferring ...
Artículo
Grey and white matter microstructure is associated with polygenic risk for schizophrenia
(Nature Publishing Group, 2021-08-30)
Recent discovery of approximately 270 common genetic variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. We hypothesized that normal variation in PRS would be ...
Artículo
A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder
(Nature Portfolio, 2020)
Understanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). We examined how cortical thickness (CT) in ASD can be parameterized as an individualized metric of ...
Artículo
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
(Royal College of Psichiatrists, 2022)
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a ...