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Artículo
Editorial: Molecular nanomachines of the presynaptic terminal
(Frontiers Research Foundation, 2016)
Artículo
Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II
(Frontiers Research Foundation, 2022)
The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit information with exquisite spatio-temporal precision, and (2) to prevent the spread of unspecific ...
Artículo
Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
(Elsevier, 2021-10-15)
Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the ...
Artículo
Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
(Frontiers Media S.A., 2022)
The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. ...
Artículo
Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal
(Frontiers Research Foundation, 2022)
Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and plastic changes in response to electrical activity. One of the main players in the regulation of ...
Artículo
Deletion of CASK in mice is lethal and impairs synaptic function
(2007)
CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central PDZ and SH3 domains, and a C-terminal guanylate kinase domain. Many potential activities for CASK ...
Artículo
In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies
(Elsevier Science INC, 2021)
Understanding the cellular underpinnings of neurodegeneration remains a challenge; loss of synapses and dendritic arborization are characteristic and can be quantified in vivo, with [11C]UCB-J PET and MRI-based Orientation ...