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Artículo
Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations
(BMC, 2022)
Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the peripheral synapse composed of a motor nerve terminal, a muscle specialization, and non-myelinating ...
Artículo
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
(NATL ACAD SCIENCES, 2019-07-18)
Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF ...
Artículo
Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal
(Frontiers Research Foundation, 2022)
Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and plastic changes in response to electrical activity. One of the main players in the regulation of ...
Artículo
The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse
(Frontiers Media S.A., 2020)
The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The NMJ is also an archetypical model to study synaptic morphology and function. As the NMJ is the primary ...
Artículo
CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
(Frontiers Media S.A., 2017-02-10)
Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an essential molecular co-chaperone that facilitates the correct folding of proteins and the assembly of ...
Artículo
Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)
Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5, which codes for the survival motor neuron (SMN) ...
Artículo
Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ
(Elsevier, 2013-06)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations in the gene encoding for IGHMBP2, an ATPase/Helicase. Paralysis of the diaphragm is an early and ...