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Artículo
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
(SOC NEUROSCIENCE, 2010)
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor ...
Artículo
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
(NATURE PUBLISHING GROUP, 2014-04-04)
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants of NMJ function. Classically, motor ...
Artículo
Editorial: Molecular nanomachines of the presynaptic terminal
(Frontiers Research Foundation, 2016)
Artículo
Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells
(1989)
The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. These cells had two major current components: a large outward current carried by K ions, and a ...
Artículo
Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
(SOC NEUROSCIENCE, 2011-02-09)
Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane called active zones (AZs). The relationships between AZs, quantal release, and vesicle replenishment ...
Artículo
Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II
(Frontiers Research Foundation, 2022)
The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit information with exquisite spatio-temporal precision, and (2) to prevent the spread of unspecific ...
Artículo
R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
(Elsevier, 2020-02-21)
Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application ...
Artículo
Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals
(SOC NEUROSCIENCE, 2009)
The spatial relationship of exocytosis and endocytosis in motor nerve terminals has been explored, with varied results, mostly in fixed preparations and without direct information on the utilization of each exocytic site. ...
Artículo
Multiple Functions of the Vesicular Proton Pump in Nerve Terminals
(Cell Press, 2010-12-22)
Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After vesicle exocytosis, continued operation of the vATPase would seem to serve no useful function. In this ...
Artículo
Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
(OXFORD UNIV PRESS, 2010)
Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. Depending on the levels of SMN protein produced from a second SMN gene (SMN2), different forms of ...