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Artículo
Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations
(BMC, 2022)
Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the peripheral synapse composed of a motor nerve terminal, a muscle specialization, and non-myelinating ...
Artículo
Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice
(Oxford University Press, 2021-04-15)
Spinal muscular atrophy (SMA) is an autosomal recessive degenerative motor neuron disease characterized by symmetrical muscle weakness and atrophy of limb and trunk muscles being the most severe genetic disease in children. ...
Artículo
SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models
(MDPI, 2022-10-20)
muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and nuclear gems and that catalyzes spliceosomal snRNP particle synthesis. In cultured motor neurons, SMN is also present in dendrites ...