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Mostrando ítems 11-20 de 20
Artículo
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation.
(Nature Research, 2016-06-23)
Sox2 is a pluripotency transcription factor that as an oncogene can also regulate cell proliferation. Therefore, genes implicated in several different aspects of cell proliferation, such as the VRK1 chromatin-kinase, are ...
Artículo
Role of aquaporins in cell proliferation: What else beyond water permeability?
(Taylor & Francis Open Access, 2016-02-21)
In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing body of evidence indicating the involvement ...
Artículo
In vivo amelioration of age-associated hallmarks by partial reprogramming
(CELL PRESS, 2016-12-15)
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has ...
Artículo
The RhoB small GTPase in physiology and disease
(2016-10-23)
RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different ...
Artículo
Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors
(WILEY, 2016)
Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is hampered by the lack of markers suitable for their prospective isolation and characterization. The carotid ...
Artículo
Association of high microvessel alpha(v)beta(3) and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126
(2016-10-26)
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. ...
Artículo
Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders
(MDPI AG, 2016-07-23)
Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings ...
Artículo
The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses
(2016-05-24)
The arrival of an action potential (AP) at a synaptic terminal elicits highly synchronized quanta release. Repetitive APs produce successive synaptic vesicle (SV) fusions that require management of spent SV components ...
Artículo
STIM and Orai1 Variants in Store-Operated Calcium Entry
(Frontiers Research Foundation, 2016-01-13)
Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma ...
Artículo
Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells
(2016-08-07)
Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the antitumoral activity of Amitriptyline, a tricyclic antidepressant, in hepatoma cells. Amitriptyline-induced ...