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Listar Artículos (Fisiología Médica y Biofísica) por autor "Tabares, Lucía"
Mostrando ítems 1-20 de 37
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Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
Ruiz Laza, Rocío; Cano, Raquel; Casañas, Juan José; Gaffield, Michael A.; Betz, William J.; Tabares, Lucía (SOC NEUROSCIENCE, 2011-02-09)Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
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Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
Ruiz Laza, Rocío; Casañas, Juan José; Torres-Benito, Laura; Cano, Raquel; Tabares, Lucía (SOC NEUROSCIENCE, 2010)Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ...
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BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
Delezie, Julien; Weihrauch, Martin; Maier, Geraldine; Tejero, Rocío; Ham, Daniel J.; Gill, Jonathan F.; Tabares, Lucía; Handschin, Christoph (NATL ACAD SCIENCES, 2019-07-18)Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and ...
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Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice
López Manzaneda, Mario; Franco Espín, Julio; Tejero Navarro, Rocío; Cano, Raquel; Tabares, Lucía (Oxford University Press, 2021-04-15)Spinal muscular atrophy (SMA) is an autosomal recessive degenerative motor neuron disease characterized by symmetrical ...
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Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction
Bertone, Nicolas Ivan; Groisman, Ayelén Ivana; Mazzone, Graciela Lujan; Cano, Raquel; Tabares, Lucía; Uchitel, Osvaldo Daniel (Wiley, 2017)Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic ...
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Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
Simon, Christian M.; Jablonka, Sibylle; Ruiz Laza, Rocío; Tabares, Lucía; Sendtner, Michael (OXFORD UNIV PRESS, 2010)Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. ...
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CSP alpha-deficiency causes massive and rapid photoreceptor degeneration
Schmitz, Frank; Tabares, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006)Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ...
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CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
López Ortega, Elena; Ruiz Laza, Rocío; Tabares, Lucía (Frontiers Media S.A., 2017-02-10)Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ...
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Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse
Ruiz Laza, Rocío; Casañas, J. J.; Südhof, T. C.; Tabares, Lucía (Wiley, 2008)Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ...
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Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells
Rey, Elkin; Hernández-Díaz, Francisco J.; Abreu, Pedro; Alonso, Rafael; Tabares, Lucía (ELSEVIER SCIENCE BV, 2001)We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 ...
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Editorial: Molecular nanomachines of the presynaptic terminal
Rizzoli, Silvio O.; Tabares, Lucía (Frontiers Research Foundation, 2016) -
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Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II
Tabares, Lucía; Rizzoli, Silvio O. (Frontiers Research Foundation, 2022)The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit ...
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Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion
Pintado, E.; Dorado, M.E.; Tabares, Lucía; López Barneo, José (1986)The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...
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Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells
Tabares, Lucía; Alés González de la Higuera, Eva María; Lindau, Manfred; Álvarez de Toledo Naranjo, Guillermo (Science Direct, 2001-08-27)Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, ...
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Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ
Krieger, Frank; Elflein, Nicole; Ruiz Laza, Rocío; Guerra, Joana; Serrano, Antonio L.; Asan, Esther; Tabares, Lucía; Jablonka, Sibylle (Elsevier, 2013-06)Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations ...
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Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations
Bermedo García, Francisca; Zelada, Diego; Martínez, Esperanza; Tabares, Lucía; Henríquez, Juan Pablo (BMC, 2022)Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the ...
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Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin
Tabares, Lucía; Ruiz Laza, Rocío; Linares Clemente, Pedro; Gaffield, Michael A.; Álvarez de Toledo Naranjo, Guillermo; Fernández-Chacón, Rafael; Betz, William J. (2007)We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ...
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Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
Arnold, Anne Sophie; Gill, Jonathan; Christe, Martine; Ruiz Laza, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (NATURE PUBLISHING GROUP, 2014-04-04)The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ...
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Multiple Functions of the Vesicular Proton Pump in Nerve Terminals
Tabares, Lucía; Betz, Bill (Cell Press, 2010-12-22)Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After ...
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Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007)Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration ...