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Listar Artículos (Fisiología Médica y Biofísica) por autor "Ortega Sáenz, Patricia"
Mostrando ítems 1-20 de 21
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Artículo
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
Bishop, Tammie; Gallagher, Denis; Pascual Bravo, Alberto; Lygate, Craig A.; Bono, Joseph P. de; Nicholls, Lynn G.; Ortega Sáenz, Patricia; Oster, Henrik; Wijeyekoon, Bhathiya; Sutherland, Andrew I.; Grosfeld, Alexandra; Aragones, Julian; Schneider, Martin; Geyte, Katie van; Teixeira, Dania; Diez Juan, Antonio; López Barneo, José; Channon, Keith M.; Maxwell, Patrick H.; Pugh, Christopher W.; Davies, Alun M.; Carmeliet, Peter; Ratcliffe, Peter J. (2008)Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the ...
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Acute oxygen sensing in heme oxygenase-2 null mice
Ortega Sáenz, Patricia; López Barneo, José; Pascual Bravo, Alberto; Gómez Díaz, Raquel (2006)Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to ...
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Carotid body chemosensory responses in mice deficient of TASK channels
Ortega Sáenz, Patricia; Levitski, Konstantín; Marcos Almaraz, María Teresa; Bonilla Henao, Victoria; Pascual Bravo, Alberto; López Barneo, José (2010)Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) ...
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Carotid body oxygen sensing and adaptation to hipoxia
López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015-09)The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
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Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; Castellano Orozco, Antonio Gonzalo; López Barneo, José (2000)Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
Gao Chen, Lin; Bonilla Henao, Victoria; García-Flores, Paula; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Wiley, 2017-09)Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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HIF-2a is essential for carotid body development and function
Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018-04-19)Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Lactate sensing mechanisms in arterial chemoreceptor cells
Torres-Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José (2021)Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative ...
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Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α
Ortega Sáenz, Patricia; Moreno Domínguez, Alejandro; Gao Chen, Lin; López Barneo, José (Frontiers Research Foundation, 2020)Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ...
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Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
Cabello Rivera, Daniel; Ortega Sáenz, Patricia; Gao Chen, Lin; Muñoz Cabello, Ana María; Bonilla-Henao, Victoria; Schumacker, Paul T.; López Barneo, José (National Academy of Sciences, 2022)Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with ...
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Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
Villadiego Luque, Francisco Javier; Muñoz-Manchado, Ana B.; Sobrino Cabello, Verónica; Bonilla-Henao, Victoria; Suárez-Luna, Nela; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; López Barneo, José; Toledo Aral, Juan José (MDPI, 2023-03-14)Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ...
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Redox signaling in acute oxygen sensing
Gao Chen, Lin; González Rodríguez, Patricia; Ortega Sáenz, Patricia; López Barneo, José (Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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Regulation of oxygen sensing by ion channels
López Barneo, José; Toro Estévez, Raquel del; Levitski, Konstantín; Chiara, María D.; Ortega Sáenz, Patricia (2004)O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or ...
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; García Fernández, María; López Barneo, José (Wiley-Blackwell Publishing Ltd., 2003)Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ...
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Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
Ortega Sáenz, Patricia; Macías Gutiérrez, David; Levitsky, Konstantin L.; Rodríguez Gómez, José Antonio; González Rodríguez, Patricia; Bonilla Henao, Victoria; Arias-Mayenco, Ignacio; López Barneo, José (2016-12)Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. ...
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The carotid body, a neurogenic niche in the adult peripheral nervous system
Pardal Redondo, Ricardo; Ortega Sáenz, Patricia; Durán, Rocío; Platero-Luengo, Aida; López Barneo, José (Univ pisa, 2010)We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...
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The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
Piruat Palomo, José Ignacio; Óscar Pintado, Carmelo; Ortega Sáenz, Patricia; Roche Molina, Marta; López Barneo, José (2004)The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the ...
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Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice
Jiménez Gómez, Blanca; Ortega Sáenz, Patricia; Gao Chen, Lin; González Rodríguez, Patricia; García-Flores, Paula; Chandel, Navdeep; López Barneo, José (NATURE PUBLISHING GROUP, 2023)The hypoxic ventilatory response (HVR) is a life-saving reflex, triggered by the activation of chemoreceptor glomus cells ...
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Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency
Al Khazal, Fatimah; Seungwoo, Kang; Holte, Molly Nelson; Choi, Doo-Sup; Singh, Ravinder; Ortega Sáenz, Patricia; López Barneo, José; Maher III, James L. (Federation amer soc exp biol, 2021)Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound ...