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Article
Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we ...
Article
Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain
(Taylor & Francis, 2019-12-02)
Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer activity of 57 extracts from 45 plants collected in Grazalema Natural Park, an area in the South of ...
Article
Dichloroacetate, 2-Deoxyglucose and a Hydroalcoholic Extract from the Skin of the Fruit of Solanum melongena (Aubergine) Induce Selective Anticancer Activity against Melanoma Cells
(Biomedical Publisher, 2013)
Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three or more sites of metastatic disease die within 1 year. Treatment failure usually occurs because the ...
Article
Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) are the standard of care for patients with metastatic renal cell carcinoma. Although these ...
Article
Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials.
(2015)
Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail ...
Article
In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylide ...
Article
A local mechanism by which alcohol consumption causes cancer
(2016)
Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of cancer is higher in tissues in closest contact on ingestion of alcohol, such as the oral cavity, ...
Article
Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data
(Biomedical Publisher, 2013)
Numerous epidemiological and preclinical studies suggest that flavonoids may play an important role in the decreased risk of cancer associated with a diet rich in plant-derived foods. In this article, we have reviewed the ...