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Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds
(Molecular Diversity Preservation International (MDPI), 2017)
Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ...
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Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanism
(Gabriele Vincenzo Gnoni, University of Salento, Italy, 2013-09-16)
Background/Objectives: Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach ...
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Oxidative stress and dietary fat type in relation to periodontal disease
(MDPI AG, 2015-04-28)
Oxidative stress is one of the main factors studied to explain the pathophysiological mechanisms of inflammatory conditions, such as periodontitis. In this respect, nutrition may be of great importance. Actually, research ...
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Utility of Periodontal exploration in patients with Fibromyalgia
(2012)
Objetive: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology, which affects predominantly women. Mitochondrial alteration could have a role in the pathophysilogical mechanisms of inflammatory ...
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Aging-Related Changes in Inflammatory and LKB1/AMPK Gene Expression in Fibromyalgia Patients
(Wiley-Blackwell Publishing Ltd., 2014-03-19)
Aging is characterized by a progressive loss of physiological integrity, leading to the impairment of numerous functions and increased vulnerability to death. This deterioration is the primary risk factor for aging‐related ...
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Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
(Mary Ann Liebert, Inc., 2013)
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the ...
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NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
(Willey, 2019-09-23)
While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive ...
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Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation
(Molecular Diversity Preservation International, 2017-06-16)
Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been ...
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Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment
(2018)
Background: Cathepsin C (CatC) is a lysosomal enzyme involved in activation of serine proteases from immune and inflammatory cells. Several loss-of-function mutations in the CatC gene have been shown to be the genetic ...