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Mostrando ítems 91-98 de 98
Artículo
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
(Springer Nature, 2021)
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase ...
Artículo
Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-12)
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy and it is identified by the presence of “nemaline bodies” (rods) in muscle fibers by histopathological examination. The most common forms of NM ...
Artículo
Dietary fatty acids in postprandial triglyceride-rich lipoproteins modulate human monocyte-derived dendritic cell maturation and activation
(MDPI, 2020)
Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins ...
Artículo
A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice
(Royal Society of Chemistry, 2020)
Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of ...
Artículo
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
(Springer Nature, 2021)
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the regulation ...
Artículo
Neuroprotective effect of rice bran enzymatic extract-supplemented diets in a murine model of Parkinsońs disease
(Elsevier, 2024-05-03)
Neurodegenerative disorders such as Parkinson's disease, present a global health concern with limited therapeutic options. In this context, dietary interventions have emerged as a potential strategy to counteract the ...
Artículo
Update on modifiable risk factors for Alzheimer’s disease and related dementias
(Wolters Kluwer, 2024)
Purpose of review. All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such as toxins, infections, traumatisms, and cardiovascular risk factors, collectively termed exposome. ...
Artículo
Electrical pulse stimulation parameters modulate N2a neuronal differentiation
(Springer Nature, 2024-01-25)
Electrical pulse stimulation has been used to enhance the differentiation or proliferation of neuronal progenitor cells in tissue engineering and cancer treatment. Therefore, a comprehensive investigation of the effects ...