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Tesis Doctoral
Estudio de los efectos producidos por la administración crónica de manganeso: implicación de la ingesta de hierro
(2005-07-14)
En la tesis titulada "Estudio de los efectos producidos por la administración crónica de manganeso: implicación de la ingesta de hierro" se ha evaluado el efecto tóxico que el manganeso, considerado un oligoelemento, puede ...
Artículo
Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress
(Eslsevier, 2013)
Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA. The activity of eEF-2 is regulated by changes in cellular ...
Artículo
Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging
(American Society for Biochemistry and Molecular Biology, 2002)
Acute and chronic treatments of mice with the gluta- thione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired the mineralocorticoid receptor (MR)- dependent biological response by inhibiting aldoster- one ...
Artículo
Time and dose dependent effects of oxidative stress induced by cumene hydroperoxide in neuronal excitability of rat motor cortex neurons
(Elsevier, 2016-03-01)
It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration and might be one factor in the development of different neurological diseases. In our study, ...
Artículo
Dysregulation of the Hippo Pathway Signaling in Aging and Cancer
(Elsevier, 2019)
Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy. In the near future, researchers will have to put even more effort into fighting these new ...
Artículo
Interim report from a 2-year double-blind RCT testing fermented papaya preparation on immune enhancement, endothelial health and QOL in elderly adults
(2023-02-27)
profile, and endothelial cell dysfunction. Indeed, increased generation of free radicals as well as immunosenescence are hallmarks of the aging process and age-related diseases. In the past 12 years or so, data has been ...
Artículo
Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide
(Wiley-Blackwell, 2017)
We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective role of exogenous melatonin on these changes in young rats treated with cumene hydroperoxide (CH), ...
Artículo
Advantages and Disadvantages of Apoptosis in the Aging Process
(Wiley-Blackwell, 2019)
Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the last century, but perhaps not always the quality of life in parallel with it. Future generations will ...
Artículo
Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
(Elsevier, 2016)
The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and neurodegenerative diseases are poorly understood. The main objective of this study was to test the effect ...
Artículo
Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex
(Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. ...