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Artículo
Biocatalytic Atroposelective Synthesis of Axially Chiral N-Arylindoles via Dynamic Kinetic Resolution
(American Chemical Society, 2022-12-22)
A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally labile N-arylindole aldehydes is described. The DKR proceeds by atroposelective bioreduction of the carbonyl group catalyzed by ...
Artículo
Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies
(Royal Society of Chemistry, 2021)
This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation of (heterobiaryl)biaryl precursors toward the synthesis of enantiomerically enriched products and ...
Artículo
Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures
(MDPI, 2021-01)
Abstract: Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for the studied reactions. ...
Artículo
Solvent-free synthesis of quaternary alpha-hydroxy alpha-trifluoromethyl diazenes: the key step of a nucleophilic formylation strategy
(Royal Society of Chemistry, 2016)
An efficient, scalable and operationally simple one-pot, 2-step strategy for the nucleophilic formylation of trifluoromethyl ketones is presented. The key step is an unprecedented diaza-carbonyl-ene reaction of formaldehyde ...
Artículo
Asymmetric Dearomatization of Phthalazines by Anion-BindingCatalysis
(American Chemical Society, 2023-12-01)
A straightforward methodology for the enantioselective synthesis of 1,2-dihydrophthalazines via dearomatization of phthalazines by anion-binding catalysis has been developed. The process involves the Mannich-type addition ...