Article
System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function
Author/s | Fernández de Cañete Rodríguez, Francisco Javier
Pimentel Naranjo, Víctor Barbancho Concejero, Julio Luque Sendra, Amalia |
Department | Universidad de Sevilla. Departamento de Tecnología Electrónica Universidad de Sevilla. Departamento de Ingeniería del Diseño |
Publication Date | 2019 |
Deposit Date | 2021-05-11 |
Published in |
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Abstract | Background and objective
The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine ... Background and objective The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems. System Dynamics is an intuitive modelling methodology based on qualitative reasoning, whereby a conceptual physiological model can be described as a set of cause–effect relationships between the physiological variables of a system, so that a set of dynamic equations describing the system behaviour quantitatively can be derived. Methods This paper presents system dynamics modelling methodology and its application for short-term arterial pressure control exerted through the baroreceptor reflex over a multi-compartmental cardiovascular model under the OpenModelica object-oriented simulation environment. Results The performance of the controlled system is analysed by simulation in light of the existing hypothesis and validation tests previously performed, demonstrating the effectiveness of the short-term regulation mechanism under physiological and pathological conditions. |
Citation | Fernández de Cañete Rodríguez, F.J., Pimentel Naranjo, V., Barbancho Concejero, J. y Luque Sendra, A. (2019). System dynamics modelling approach in Health Sciences. Application to the regulation of the cardiovascular function. Informatics in Medicine Unlocked, 15, 100164-. |
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