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Artículo
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
(American Society for Biochemistry and Molecular Biology Inc., 2003)
THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and export such as Sub2 and Yra1. Mutations in any of the THO/TREX structural genes cause pleiotropic ...
Artículo
Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
(2020-04-24)
Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) ...
Artículo
Conjugal transfer of the Salmonella enterica virulence plasmid in the mouse intestine
(American Society for Microbiology, 2008)
BALB/c mice were infected with two Salmonella enterica serovar Typhimurium strains, one of which lacked the virulence plasmid. Transconjugants were found at high frequencies in the mouse feces and at low frequencies in the ...
Artículo
Prefoldin-like Bud27 influences the transcription of ribosomal components and ribosome biogenesis in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2020)
Understanding the functional connection that occurs for the three nuclear RNA polymerases to synthesize ribosome components during the ribosome biogenesis process has been the focal point of extensive research. To preserve ...
Tesis Doctoral
Artículo
Fluorescent calixarene-schiff as a nanovehicle with biomedical purposes
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-07-14)
Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. ...
Artículo
Fungal Secondary Metabolism
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Definition: Fungal secondary metabolites (SMs) comprise a vast collection of compounds expendable for these organisms under laboratory conditions. They exhibit enormous chemical diversity, and usu- ally belong to four ...
Tesis Doctoral
Control metabólico de la sensibilidad a TRAIL en células epiteliales de mama : papel de AMPK
(2009)
La apoptosis es el mecanismo por el cual las células son eliminadas del organismo tras una serie de procesos bioquímicos controlados, en ausencia de procesos inflamatorios que dañen a los tejidos circundantes. El ligando ...
Tesis Doctoral
Implicaciones biológicas de las interacciones con proteínas del hospedador de SseK1 y SlrP, dos efectores de los sistemas de secreción tipo III de Salmonella
(2021-10-20)
Salmonella enterica es una especie de bacteria patógena Gram negativa que puede producir diferentes enfermedades, desde gastroenteritis a enfermedades sistémicas. S. enterica posee dos sistemas de secreción de tipo III ...
Artículo
TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells
(Springer Nature, 2019)
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation. ...