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Tesis Doctoral
Inestabilidad genética asociada a defectos en el complejo TFIIH
(2010)
Los organismos eucarióticos poseen múltiples mecanismos para preservar la integridad de su información genética. Ésta puede verse comprometida por agentes genotóxicos externos o metabolitos dañinos de la propia célula, así ...
Tesis Doctoral
Transcriptional regulation by the Velvet complex during development in Neurospora crassa
(2023-04-21)
Developmental transitions in fungi are key to their success in colonizing new habitats and adapting to stressful environmental conditions. Developmental transitions are regulated by environmental factors such as light. ...
Artículo
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are ...
Artículo
TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023-11-09)
DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 but can occasionally become abortive generating permanent protein-linked single strand breaks (SSBs). ...
Tesis Doctoral
Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
(2023-07-07)
Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de doble cadena del ADN (DSBs) la lesión más citotóxica para la célula. Numerosos estudios han mostrado ...
Artículo
Three Genes Involved in Different Signaling Pathways, carS, wcoA, and acyA, Participate in the Regulation of Fusarin Biosynthesis in Fusarium fujikuroi
(MDPI, 2024)
The phytopathogenic fungus Fusarium fujikuroi has a rich secondary metabolism which includes the synthesis of very different metabolites in response to diverse environmental cues, such as light or nitrogen. Here, we focused ...
Artículo
Rat1 promotes premature transcription termination at R-loops
(Oxford University Press, 2024-04-24)
Certain DNA sequences can adopt a non-B form in the genome that interfere with DNA-templated processes, including transcription. Among the sequences that are intrinsically difficult to transcribe are those that tend to ...
Artículo
SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
(CELL PRESS (Elsevier), 2024)
During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication factors or nucleotides. A limited number of histone post-translational modifications at stalled RFs ...