Buscar
Mostrando ítems 1-10 de 29
Artículo
Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Neuroinflammation underlies neurodegenerative diseases. Herein, we test whether acute colon inflammation activates microglia and astrocytes, induces neuroinflammation, disturbs neuron intrinsic electrical properties in the ...
Artículo
Relationship between insulin-biochemical resistance levels and the degree of depression and anxiety in patients from Honduras
(SPRINGER INDIA, 2022)
Background/purpose Many studies suggest that insulin resistance in obese patients bridges mental illness. Our objective was to identify the association between levels of depression and anxiety with insulin resistance, and ...
Artículo
Histological Methods to Assess Skeletal Muscle Degeneration and Regeneration in Duchenne Muscular Dystrophy
(MDPI, 2022)
Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of function of the protein dystrophin. This protein contributes to the stabilisation of striated cells during contraction, as it anchors the ...
Artículo
Oxidative and Inflammatory Imbalance in Placenta and Kidney of sFlt1-Induced Early-Onset Preeclampsia Rat Model
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Preeclampsia (PE) is a pregnancy-specific disorder characterized by the new onset of hypertension plus proteinuria and/or end-organ dysfunction. Here, we investigate the role of the nicotinamide adenine dinucleotide phosphate ...
Artículo
Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy
(Frontiers Media, 2022)
Background: Duchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression. Previously, we reported ...
Artículo
Emerging pharmacological treatment options for MAFLD
(2022)
Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated with metabolic comorbidities, obesity, overweight, type 2 diabetes mellitus, and at least two ...
Artículo
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
(MDPI AG, 2022)
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced ...
Artículo
The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Selenium (Se) is an essential trace element mainly known for its antioxidant, an-ti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins. Some of them are related ...
Artículo
VEGF and Neuronal Survival
(SAGE, 2022)
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a neuroprotective action of this factor on injured or diseased neurons. In the present review, we summarize ...
Artículo
Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
(Wiley Open Access, 2022-10-16)
Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction ...