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Mostrando ítems 11-19 de 19
Artículo
Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the ...
Artículo
Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro
(MDPI, 2021)
Neural progenitor cells (NPCs) are self-renewing and multipotent cells that persist in the postnatal and adult brain in the subventricular zone and the hippocampus. NPCs can be expanded in vitro to be used in cell therapy. ...
Artículo
Palisade endings have an exocytotic machinery but lack acetylcholine receptors and distinct acetylcholinesterase activity
(ARVO, 2020)
Purpose: The purpose of this work was to test whether palisade endings express structural and molecular features of exocytotic machinery, and are associated with acetylcholine receptors, and enzymes for neurotransmitter ...
Artículo
Age-Dependent Vulnerability to Oxidative Stress of Postnatal Rat Pyramidal Motor Cortex Neurons
(MDPI, 2020-12)
Oxidative stress is one of the main proposed mechanisms involved in neuronal degeneration. To evaluate the consequences of oxidative stress on motor cortex pyramidal neurons during postnatal development, rats were ...
Artículo
Microbiota-liver-bile salts axis, a novel mechanism involved in the contrasting effects of sodium selenite and selenium-nanoparticle supplementation on adipose tissue development in adolescent rats
(MDPI, 2023)
Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects ...
Artículo
Phorbol Diesters and 12-Deoxy-16-hydroxyphorbol 13,16-Diesters Induce TGFα Release and Adult Mouse Neurogenesis
(American Chemical Society, 2021)
A small library of phorbol 12,13-diesters bearing low lipophilicity ester chains was prepared as potential neurogenic agents in the adult brain. They were also used in a targeted UHPLC–HRMS screening of the latex of Euphorbia ...
Artículo
Different effects of low selenite and selenium-nanoparticle supplementation on adipose tissue function and insulin secretion in adolescent male rats
(MDPI, 2022)
Adolescence is a period of intense growth and endocrine changes, and obesity and insulin-resistance processes during this period have lately been rising. Selenium (Se) homeostasis is related to lipid metabolism depending ...
Artículo
Response to glecaprevir/pibrentasvir in HIV/HCV-coinfected patients in clinical practice
(Oxford University Press, 2023-09-06)
HIV infection has been associated with lower rates of sustained viral response (SVR) with direct-acting antivirals (DAAs). There are few data on glecaprevir/pibrentasvir (G/P) in HIV/HCV coinfection outside clinical trials.
Artículo
High efficacy of glecaprevir/pibrentasvir for HCV-infected individuals with active drug use
(Elsevier, 2022-09)
Objectives Real world data on glecaprevir/pibrentasvir (G/P) among active drug users are scarce. We evaluated the sustained virological response (SVR) rates of G/P among individuals with and without active drug use in ...