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Mostrando ítems 11-20 de 38
Artículo
Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into ...
Artículo
Role of Vascular Endothelial Growth Factor as a Critical Neurotrophic Factor for the Survival and Physiology of Motoneurons
(Wolters Kluwer Health, 2023)
Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity. However, during evolution, it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates ...
Artículo
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF
(Springer Nature, 2023)
The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to changes in Cl− homeostasis and, consequently, in the polarity and amplitude of inhibitory synaptic ...
Artículo
Reelin Protects against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions ...
Artículo
Relative contribution of lateral vestibular neuron and abducens internuclear neuron inputs to the discharge activity of medial rectus motoneurons
(Springer, 2023)
Medial rectus motoneurons mediate nasally directed horizontal eye movements. These motoneurons receive two major excitatory inputs, from the abducens internuclear neurons (ABD Ints) and neurons of the lateral vestibular ...
Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether ...
Artículo
Sources and lesion-induced changes of VEGF expression in brainstem motoneurons
(Springer Nature, 2020-04-01)
Motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration compared to other cranial motoneurons, as seen in amyotrophic lateral sclerosis (ALS). The overexpression of vascular endothelial growth ...
Artículo
Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action
(Springer Nature, 2021)
Hippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry ...
Artículo
Eye Movements But Not Vision Drive the Development of Palisade Endings
(Association for Research in Vision and Ophthalmology, 2022)
PURPOSE. To test whether visual experience and/or eye movements drive the postnatal development of palisade endings in extraocular muscles. METHODS. In three newborn cats, the right eye was covered until 30 days from ...
Artículo
VEGF is an essential retrograde trophic factor for motoneurons
(National Academy of Sciences, 2022)
VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endothelial growth factor."However, its more recently discovered neurotrophic activity may be evolutionarily more ancient. Our ...