Artículo
Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease
Título alternativo | Células neuronales derivadas de células madre pluripotentes humanas como plataforma relevante para la detección de fármacos en la enfermedad de Alzheimer |
Autor/es | García León, Juan Antonio
Cáceres Palomo, Laura Sánchez Mejías, Elisabeth Mejías Ortega, Marina Núñez Díaz, Cristina Fernández Valenzuela, Juan José Sánchez Varo, Raquel María Dávila Cansino, José Carlos Vitorica Ferrández, Francisco Javier Gutiérrez, Antonia |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-12-15 |
Publicado en |
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Resumen | Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still notfully understood, since different ... Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still notfully understood, since different neural cell types are involved in the disease. Although neuronalfunction is clearly deteriorated in AD patients, recently, an increasing number of evidences havepointed towards glial cell dysfunction as one of the main causative phenomena implicated in ADpathogenesis. The complex disease pathology together with the lack of reliable disease models haveprecluded the development of effective therapies able to counteract disease progression. The discoveryand implementation of human pluripotent stem cell technology represents an important opportunityin this field, as this system allows the generation of patient-derived cells to be used for diseasemodeling and therapeutic target identification and as a platform to be employed in drug discoveryprograms. In this review, we discuss the current studies using human pluripotent stem cells focusedon AD, providing convincing evidences that this system is an excellent opportunity to advance inthe comprehension of AD pathology, which will be translated to the development of the still missingeffective therapies. |
Agencias financiadoras | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Consejería de Economía y Conocimiento, Junta de Andalucía |
Identificador del proyecto | PI18/01557
PI18/01556 CB06/05/1116 CB06/05/0094 UMA18-FEDERJA-211 PY18-RT-223 US-12627 |
Cita | García León, J.A., Cáceres Palomo, L., Sánchez Mejías, E., Mejías Ortega, M., Núñez Díaz, C., Fernández Valenzuela, J.J.,...,Gutiérrez, A. (2020). Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease. International Journal of Molecular Sciences, 21 (18), 1-48. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Células neuronales.pdf | 2.564Mb | [PDF] | Ver/ | |