Artículo
EpiGraph: an open-source platform to quantify epithelial organization
Autor/es | Vicente Munuera, Pablo
Gómez Gálvez, Pedro Tetley, Robert J. Forja Barbosa, Cristina Tagua Jáñez, Antonio Jesús Letrán, Marta Tozluoglu, Melda Mao, Yanlan Escudero Cuadrado, Luis María |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-12-12 |
Publicado en |
|
Resumen | Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ... Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond the traditional polygon distribution analysis, capturing other organizational traits that improve the characterization of epithelia. EpiGraph can objectively compare the rearrangements of epithelial cells during development and homeostasis to quantify how the global ensemble is affected. Importantly, it has been implemented in the open-access platform Fiji. This makes EpiGraph very user friendly, with no programming skills required. |
Agencias financiadoras | Ministerio de Economia, Industria y Competitividad (MINECO). España |
Identificador del proyecto | BFU2016-74975-P
PI13/ 01347 |
Cita | Vicente Munuera, P., Gómez Gálvez, P., Tetley, R.J., Forja Barbosa, C., Tagua Jáñez, A.J., Letrán, M.,...,Escudero Cuadrado, L.M. (2020). EpiGraph: an open-source platform to quantify epithelial organization. Bioinformatics, 36 (4), 1314-1316. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
pubbtz683.pdf | 1.125Mb | [PDF] | Ver/ | |