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Listar por autor "Mora Santos, María del Mar"
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Tesis Doctoral
Análisis Funcional de la Fosforilación de Securina
Mora Santos, María del Mar (2011)El objetivo de esta Tesis se engloba dentro de un estudio más amplio sobre el análisis funcional de la fosforilación de ...
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Artículo
Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
Belmonte Fernández, Alejandro; Herrero Ruiz, Joaquín; Galindo Moreno, María; Limón Mortés, María Cristina; Mora Santos, María del Mar; Sáez, Carmen; Japón, Miguel A.; Tortolero García, María Dolores; Romero Portillo, Francisco (Springer Nature, 2023)Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ...
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Artículo
Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation
Maldonado y Aibar, María Dolores; Mora Santos, María del Mar; Naji, L.; Carrascosa-Salmoral, M. P.; Naranjo, M. C.; Calvo Gutiérrez, Juan Ramón (Elsevier, 2010)Mast cells take part of armamentarium immunologic for host defense against parasitic and bacterial infections. They are ...
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Artículo
Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
Mora Santos, María del Mar; Limón Mortés, María Cristina; Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (The American Society for Biochemistry and Molecular Biology, 2011)PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ...
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Artículo
SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability
Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Impact Journals LLC, 2014)The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response ...
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Artículo
UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase
Limón Mortés, María Cristina; Mora Santos, María del Mar; Espina Zambrano, Águeda Gema; Pintor Toro, José Antonio; López Román, Antonio; Tortolero García, María Dolores; Romero Portillo, Francisco (Company of Biologists, 2008)Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid ...
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Artículo
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Giraldez Macias, Servando; Sáez Torres, Carmen; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (Impact Journals, 2014)n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the ...