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Listar por autor "Helleday, Thomas"
Mostrando ítems 1-6 de 6
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Artículo
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013)5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
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Artículo
Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
Groth, Petra; Orta Vázquez, Manuel Luis; Elvers, Ingegerd; Majumder, Muntasir Mamun; Lagerqvist, Anne; Helleday, Thomas (Oxford University Press, 2012)Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end ...
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Artículo
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann, Eva; Orta Vázquez, Manuel Luis; Issaeva, Natalia; Schultz, Niklas; Helleday, Thomas (Elsevier, 2010)Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results ...
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Artículo
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
Henriksson, Sofia; Calderón Montaño, José Manuel; Solvie, Daniel; Warpman Berglund, Ulrika; Helleday, Thomas (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...
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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; López Lázaro, Miguel; Helleday, Thomas (Oxford University Press, 2014)Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ...
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Artículo
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Orta Vázquez, Manuel Luis; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; Domínguez García, Inmaculada; Calderón Montaño, José Manuel; Huertas Castaño, Carlos; López Lázaro, Miguel; Helleday, Thomas; Mateos Cordero, Santiago (Elsevier, 2017)Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...