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Listar por autor "Gauthier, Benoit R."
Mostrando ítems 1-13 de 13
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Artículo
Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
Gauthier, Benoit R.; Rubio Contreras, Diana; Gómez Rosado, Juan Carlos; Capitán Morales, Luis Cristobal; Hmadcha, Abdelkrim; Soria, Bernat; Lachaud, Christian Claude (MDPI, 2022)Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral ...
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Artículo
Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
Lorenzo, Petra I.; Jiménez Moreno, Carmen María; Delgado, Irene; Cobo Vuilleumier, Nadia; Meier, Rafael; Gómez Izquierdo, Lourdes; Berney, Thierry; García Carbonero, Rocío; Rojas, Anabel; Gauthier, Benoit R. (Springer Verlag, 2011)The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well as the urinary and ...
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Artículo
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo Vuilleumier, Nadia; Lorenzo, Petra I.; García Rodríguez, Noelia; Herrera Gómez, Irene G.; Fuente Martín, Esther; López Noriega, Livia; Mellado Gil, José Manuel; Romero Zerbo, Silvana Y.; Lachaud, Christian; Hmadcha, Abdelkrim; Sánchez Palazón, Luis; Martín Montalvo, Alejandro; Soria Escoms, Bernat; Gauthier, Benoit R. (Nature Publishing Group, 2018-04-16)Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies ...
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Artículo
Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus
Lorenzo, Petra I.; Martín Montalvo, Alejandro; Cobo Vuilleumier, Nadia; Gauthier, Benoit R. (Multidisciplinary Digital Publishing Institute (MDPI), 2019)Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...
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Artículo
Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation
Gauthier, Benoit R.; Comaills, Valentine (Multidisciplinary Digital Publishing Institute (MDPI), 2021)The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...
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Artículo
PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
Mellado Gil, José Manuel; Jiménez Moreno, Carmen María; Martín Montalvo, Alejandro; Álvarez Mercado, Anabel; Fuente Martín, Esther; Cobo Vuilleumier, Nadia; Lorenzo, Petra I.; Gracia Herrera Gómez, Irene de; López Noriega, Livia; Quesada, Iván; Gauthier, Benoit R. (Springer Nature, 2016)[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, ...
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Artículo
The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice
Romero Zerbo, Silvana Y.; Ruz Maldonado, Inmaculada; Espinosa Jiménez, Vanesa; Cobo Vuilleumier, Nadia; Gauthier, Benoit R. (Nature Publishing Group, 2017)LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology ...
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Artículo
The diabetes-linked transcription factor PAX4: from gene to functional consequences
Lorenzo, Petra I.; Juárez Vicente, Francisco; Cobo Vuilleumier, Nadia; García Domínguez, Mario; Gauthier, Benoit R. (MDPI, 2017)Paired box 4 (PAX4) is a key factor in the generation of insulin producing β-cells during embryonic development. In adult ...
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Artículo
The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
Lorenzo, Petra I.; Martín Vázquez, Eugenia; López-Noriega, Livia; Fuente-Martín, Esther; Mellado-Gil, José M.; Franco, Jaime M.; Rivero Canalejo, Sabrina; Pozo Pérez, David; Gauthier, Benoit R. (IVYSPRING INT PUBL, 2021)Rationale: We recently demonstrated that the ‘Metabesity’ factor HMG20A regulates islet beta-cell functional maturity ...
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Artículo
The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity article
Mellado Gil, José Manuel; Fuente Martín, Esther; Lorenzo Ovejero, Petra Isabel; Cobo Vuilleumier, Nadia; López Noriega, Livia; Martín Montalvo, Alejandro; Gracia Herrera Gómez, Irene de; Ceballos Chávez, María; Romero Zerbo, Silvana Y.; Hmadcha, Abdelkrim; Soria Escoms, Bernat; Bermúdez Silva, Francisco Javier; Reyes, José C.; Gauthier, Benoit R. (Springer Nature [academic journals on nature.com, 2018)HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small ...
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Artículo
Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
Hmadcha, Abdelkrim; Martín Montalvo, Alejandro; Gauthier, Benoit R.; Soria Escoms, Bernat; Capilla González, Vivian (Frontiers Media S.A., 2020)Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of ...
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Artículo
Thyroid hormones in diabetes, cancer, and aging
Gauthier, Benoit R.; Sola García, Alejandro; Cáliz Molina, María Ángeles; Lorenzo, Petra Isabel; Cobo Vuilleumier, Nadia (Wiley, 2020)Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...
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Tesis Doctoral
Two novel therapies for the treatment of type 1 diabetes mellitus.
Herrera Gómez, Irene G. (2019-01-14)Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of islet β cells. Current treatments are based on ...